In 1914 at age fourteen, Eduardo enters permanently into the company's half-brother Vincenzo Scarpetta, in which Edward does everything, from Dresser, all'attrezzista, the prompter, the master, and stays there until it is called for military service , from 1920 to 1922, but not before publishing his first one-act "Pharmacy on duty" in 1920. But even during his military service his artistic effort was so intense and so that in his spare time he went into theater acting.
After the military Filippo De Vincenzo Scarpetta leaves the company to switch to that of Francis Corbinci, which debuts for the first time in a busy director, the theater in Via Partenope in Naples with Foria "Surriento gentle" Enzo Lucio Murolo .
In 1922 he wrote and directed another of his play, "Man and honest man.
"Eduardo leaves the company of Francis Corbinci to return to the brother of Vincent and remains there until 1930.In this period he met and married Dorothy Pennington an American on holiday in Italy and also starred in other companies such as Michael Galdieri and Cariniù Falcons.Under the pseudonym in 1929 Tricot writes the one-act "Sik Sik the magical creator.
"Peppino with his brothers and Titina in 1931, he founded the company of "The Theater Humor De Filippo." In this period, he works as the author writes of the value of "Christmas at Cupiello" (1931) and "Who's cchiù happy 'and me?" (1932) and at the same time began an intense film with "Three Men in a tuxedo" (1932) by Mario Bonnard, followed by "The Three Cornered Hat" (1934) Mario Camerini and "Those two" (1935) of Gennaro Righelli.
In 1945, he writes, "Naples millionaire" and finally snaps the artistic relationship with Peppino, for which their company is dissolved. So Eduardo gives life to the "Society of Eduardo", which is in 1946 "Ghosts" and shortly thereafter, with a triumphant outcome, "Filumena Marturano", destined to become a workhorse of the great Titina.Hence it is always growing with other masterpieces like "Your lies with long legs" (1947), "The great magic" (1948), "The voices from within" (1948), "The number one fear" (1951 ) that enrich a repertoire more and more out of the ordinary, while the film runs "Assunta Spina" (1948, M. Mattioli), "Naples Millionaire" (1950), "Filumena Marturano" (1951), 'L' Gold of Naples "(1954, by V. De Sica)," Ghosts in Rome "(1960, by A. Pietrangeli).
Eduardo has great satisfaction in 1958, when it is performed in Moscow, directed by R. Simonov, "Filumena Marturano" and, in 1962, "The mayor of the district health".
In 1964, he wrote "The art of comedy," compared to "The Impromptu" by Moliere;1973 is another year of great satisfaction: staging "tests never end" and is represented "Saturday, Sunday and Monday", directed by Franco Zeffirelli at the Old Vic in London with the interpretation of Laurence Olivier .A crown of his incredible career in November of 1980, he was conferred the honorary degree in literature from the University of Rome and was appointed senator for life in 1981.
Eduardo died October 31, 1984, in the Roman Villa Stuart clinic where he was admitted a few days before.